Title of article
Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction
Author/Authors
McNamara، نويسنده , , Catherine Anne and King، نويسنده , , Frank and Bradley، نويسنده , , Mark، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
8239
To page
8243
Abstract
Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0TM.
Keywords
Design , PALLADIUM , Polymer , Supported
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843731
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