Title of article
Total synthesis of (+)-tanikolide, a toxic and antifungal δ-lactone, utilizing bromoalkene intermediates conveniently synthesized from vicinal dibromoalkane by regioselective elimination
Author/Authors
Ohgiya، نويسنده , , Tadaaki and Nishiyama، نويسنده , , Shigeru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
8273
To page
8275
Abstract
Stereoselective total synthesis of (+)-tanikolide, a bioactive δ-lactone marine natural product, was successfully accomplished by using regioselective HBr elimination reaction of 3-acyloxy-1,2-dibromoalkanes, Pd-mediated coupling reaction, and the Sharpless asymmetric epoxidation as key steps.
Keywords
Antifungal lactone , Bromoalkene , Regioselective elimination , tanikolide , Lyngbia majuscula
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843742
Link To Document