Title of article
Synthesis of Cinacalcet congeners
Author/Authors
Wang، نويسنده , , Xin and Chen، نويسنده , , Ying and Crockett، نويسنده , , Richard and Briones، نويسنده , , Jorge and Yan، نويسنده , , Tony and Orihuela، نويسنده , , Carlos and Zhi، نويسنده , , Benxin and Ng، نويسنده , , John، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
8355
To page
8358
Abstract
Two racemic isomeric dihydronaphthalenes 1 and 2 were prepared from commercially available 5-hydroxytetralone in five linear steps. A key palladium-catalyzed double bond migration led to the synthesis of both isomers from the same starting material. Preparative chiral HPLC separation provided the enantiomerically pure materials. An asymmetric synthesis employing CBS reduction to furnish 1 was also developed.
Keywords
Dihydronaphthalene , Double bond migration , Cinacalcet
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843794
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