Title of article
Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan
Author/Authors
Nguyen، نويسنده , , Mai Thanh Thi and Awale، نويسنده , , Suresh and Tezuka، نويسنده , , Yasuhiro and Tran، نويسنده , , Quan Le and Kadota، نويسنده , , Shigetoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
8519
To page
8522
Abstract
A novel dimeric methanodibenzoxocinone, named neosappanone A (1), possessing a unique unprecedented novel carbon framework, has been isolated from the heartwood of Caesalpinia sappan L. of Vietnam, and its structure was elucidated on the basis of spectroscopic analysis. Neosappanone A (1) competitively inhibited xanthine oxidase in a concentration-dependent manner (IC50, 29.7 μM; Ki, 16.3 μM).
Keywords
Dimeric methanodibenzoxocinone , Caesalpinia sappan , Xanthine oxidase (XO) inhibitory activity , new carbon skeleton
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843857
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