Title of article
N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis
Author/Authors
Kotha، نويسنده , , Sambasivarao and Singh، نويسنده , , Kuldeep، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
9607
To page
9610
Abstract
An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C- and N-alkenylated products gave cyclic amino acid derivatives in good yields.
Keywords
Regioselective N-alkylation , Diethyl acetamidomalonate , metathesis , Constrained amino acid derivatives , Heterocycles
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844284
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