Title of article
A new synthesis of β-keto amides by reduction of Passerini adducts
Author/Authors
Neo، نويسنده , , Ana G. and Delgado، نويسنده , , Jose M. Polo، نويسنده , , Cecilia and Marcaccini، نويسنده , , Stefano and Marcos، نويسنده , , Carlos F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
23
To page
26
Abstract
The Passerini reaction between glyoxals, isocyanides and acetic acid forms β-keto acyloxyamides, which are readily transformed in β-keto amides by reductive deacetoxylation with zinc. The versatility of this procedure, which allows introducing different groups both in position-3 and the amide nitrogen, makes it ideal for its use in diversity-oriented synthesis, in combination with subsequent complexity generation reactions.
Keywords
Isocyanides , multicomponent reactions , Amido-ketones , Ultrasounds
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844316
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