Title of article
Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan
Author/Authors
Kramp، نويسنده , , Kari L. and DeWitt، نويسنده , , Kristin and Flora، نويسنده , , Jason W. and Muddiman، نويسنده , , David C. and Slunt، نويسنده , , Kelli M. and Houston، نويسنده , , Todd A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
695
To page
698
Abstract
The Leishmania lipophosphoglycan (LPG) is the most abundant cell surface glycoconjugate of a family of infectious protozoa. Pentamidine, a common drug used in the treatment of Leishmania infections, has been modified with boronic acids so that it might bind more selectively to the phosphodisaccharide repeating unit of the LPG. This could serve to target the drug to the protozoan surface and increase its efficacy in vivo.
Keywords
Boronate drug targeting , Pentamidine , Leishmania
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844587
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