Title of article
Cyclopropane PNA: observable triplex melting in a PNA constrained with a 3-membered ring
Author/Authors
Pokorski، نويسنده , , Jonathan K. and Myers، نويسنده , , Michael C. and Appella، نويسنده , , Daniel H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
915
To page
917
Abstract
The first peptide nucleic acid (PNA) with a cyclopropane in the backbone has been synthesized, and the effects of the ring on DNA/RNA binding properties of the PNA have been examined. Well-defined triplex to duplex melting transitions of PNA2 DNA complexes is clearly observed by variable temperature UV absorbance with the cyclopropane-constrained PNA.
Keywords
PNA , Cyclopropane , peptide nucleic acid
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844675
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