Title of article
One-step synthesis of 2-arylbenzothiazole (‘BTA’) and -benzoxazole precursors for in vivo imaging of β-amyloid plaques
Author/Authors
David Alagille، نويسنده , , David and Baldwin، نويسنده , , Ronald M. and Tamagnan، نويسنده , , Gilles D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1349
To page
1351
Abstract
We report the simple and efficient synthesis of 2-arylbenzothiazoles (‘BTA’) and 2-arylbenzoxazoles by direct coupling of benzothiazoles or benzoxazoles with aryl bromides. This method permits direct one-step access to precursors of radiolabeled BTA-1 and BTA-2 and their 6-methoxy analogues, used for in vivo imaging of β-amyloid plaques with positron emission tomography (PET).
Keywords
2-Arylbenzothiazole , 2-Arylbenzoxazole , BTA , Amyloid plaques , PALLADIUM , Direct coupling
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844863
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