Title of article
A d,l-proline catalyzed diastereoselective trimolecular condensation: an approach to the one-pot synthesis of perhydrofuro[3,2-b]pyran-5-ones
Author/Authors
Sabitha، نويسنده , , Gowravaram and Raj Kumar، نويسنده , , M. and Shashi Kumar Reddy، نويسنده , , M. and Yadav، نويسنده , , J.S and Rama Krishna، نويسنده , , K.V.S. and Kunwar، نويسنده , , A.C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1659
To page
1661
Abstract
d,l-Proline was found to catalyze efficiently the one-pot trimolecular condensation of indoles, a sugar hydroxyaldehyde, and Meldrum’s acid followed by intramolecular cyclization with evolution of carbon dioxide and elimination of acetone to afford 7-(1H-3-indolyl)-2,3-dimethoxyperhydrofuro[3,2-b]pyran-5-ones. The reaction proceeded cleanly at ambient temperature to afford the products in good yields with high diastereoselectivity.
Keywords
Furo-pyranone , trimolecular condensation , indole , d , L-proline
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844990
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