Title of article
Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation
Author/Authors
Daouda Minta، نويسنده , , Ewelina and Boutonnet، نويسنده , , Cédric and Boutard، نويسنده , , Nicolas and Martinez، نويسنده , , Jean-Paul Rolland، نويسنده , , Valérie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1795
To page
1797
Abstract
Alkali metal trimethylsilanolates, TMSO−, M+, has been used for efficient conversion of methyl esters into their corresponding anhydrous acid salts under mild non-aqueous conditions. This strategy has been applied to SPPS for the preparation of neurotoxin cyclic analogues and in (S)-5-hydroxynorvaline synthesis.
Keywords
SPPS , Sodium and potassium silanolates , aminoacids , Glu , selective deprotection , ASP
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845050
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