Title of article
A new synthesis of β-amino acids by use of ketene diethyl acetal as enolate equivalent
Author/Authors
Rossen، نويسنده , , Kai and Jakubec، نويسنده , , Pavol and Kiesel، نويسنده , , Michael J. Janik، نويسنده , , Matthias، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1819
To page
1821
Abstract
Reaction of phenylsulfonyl formamides, readily available in a single step from an aromatic aldehyde and sodium phenylsulfinate, with ketene diethyl acetal under basic conditions gives N-formyl β-amino acid esters in good yield, which can be kinetically resolved with a lipase.
Keywords
Acetate enolate , Enzymic kinetic resolution , ?-Amino acid , Ketene diethylacetal , Acyl imine
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845064
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