Title of article
A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides
Author/Authors
Marcin Kalek، نويسنده , , Marcin and Jemielity، نويسنده , , Jacek and Stepinski، نويسنده , , Janusz and Stolarski، نويسنده , , Ryszard and Darzynkiewicz، نويسنده , , Edward، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
2417
To page
2421
Abstract
An efficient method for the preparation of nucleoside 5′-methylenebis(phosphonate)s has been developed. Unprotected nucleosides are phosphonylated directly with methylenebis(phosphonic dichloride). Reaction conditions were optimized to prevent side product formation.
Keywords
nucleosides , bisphosphonates , Nucleotides , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845282
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