Title of article
A base-catalyzed, direct synthesis of 3,5-disubstituted 1,2,4-triazoles from nitriles and hydrazides
Author/Authors
Yeung، نويسنده , , Kap-Sun and Farkas، نويسنده , , Michelle E. and Kadow، نويسنده , , John F. and Meanwell، نويسنده , , Nicholas A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3429
To page
3432
Abstract
A convenient and efficient one step, base-catalyzed synthesis of 3,5-disubstituted 1,2,4-triazoles by the condensation of a nitrile and a hydrazide is presented. A diverse range of functionality and heterocycles are tolerated under the reaction conditions developed, and the reactivity of the nitrile partner is relatively insensitive to electronic effects.
Keywords
1 , microwave , solution phase synthesis , Hydrazide , 4-Triazole , Nitriles , 2
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845629
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