Title of article
Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling
Author/Authors
Paterson، نويسنده , , Ian and Menche، نويسنده , , Dirk and Britton، نويسنده , , Robert and H?kansson، نويسنده , , Anders E. and Silva-Mart??nez، نويسنده , , Mar??a ?.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
6
From page
3677
To page
3682
Abstract
The solution structures of the potent microtubule-stabilizing anti-cancer agent laulimalide and simplified analogues were determined by a combination of high field 1H NMR spectroscopic studies (J-based configuration analysis and NOESY) and constrained molecular dynamics simulations and discussed in relation to their antiproliferative activity.
Keywords
conformational analysis , Analogues , solution structure , Laulimalide , Anti-cancer agent , Modelling
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845730
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