• Title of article

    Synthesis of the fungal natural product (−)-xylariamide A

  • Author/Authors

    Davis، نويسنده , , Rohan A. and Kotiw، نويسنده , , Michael، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2005
  • Pages
    3
  • From page
    5199
  • To page
    5201
  • Abstract
    The first synthesis of the fungal natural product (−)-xylariamide A 1 is reported. N,O-Bis(trimethylsilyl)acetamide induced coupling of d-tyrosine with (E)-but-2-enedioic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester 5 produced the dechloro natural product 6, which was subsequently monochlorinated using oxone and KCl to yield synthetic 1. (−)-Xylariamide A 1, (+)-xylariamide A 2 and (−)-dechloroxylariamide A 6 displayed no cytotoxic or antimicrobial activity.
  • Keywords
    O-Bis(trimethylsilyl)acetamide , (+)-Xylariamide A , (?)-Dechloroxylariamide A , Synthesis , (?)-Xylariamide A , natural product , N
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2005
  • Journal title
    Tetrahedron Letters
  • Record number

    1846277

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1846277