Title of article
Synthesis of non-THF analogs of acetogenin toward simplified mimics
Author/Authors
Fujita، نويسنده , , Daisuke and Ichimaru، نويسنده , , Naoya and Abe، نويسنده , , Masato and Murai، نويسنده , , Masatoshi and Hamada، نويسنده , , Takeshi and Nishioka، نويسنده , , Takaaki and Miyoshi، نويسنده , , Hideto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
5775
To page
5779
Abstract
Acetogenin analogs in which the bis-adjacent THF ring was replaced with an enantioselectively synthesized 1,2-cyclopentanediol bis-ether skeleton were synthesized to obtain simplified mimics, and their inhibitory effect on mitochondrial NADH–ubiquinone oxidoreductase (complex I) was examined. The results clearly demonstrate that the 1,2-cyclopentanediol bis-ether motif can substitute for the bis-THF ring while maintaining very potent inhibitory activity at the nanomolar level.
Keywords
Acetogenin , Mitochondrial complex I , Structure–activity relationship
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846486
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