Title of article
Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition
Author/Authors
Ding، نويسنده , , Ke and Wang، نويسنده , , Guoping and Deschamps، نويسنده , , Jeffrey R. and Parrish، نويسنده , , Damon A. and Wang، نويسنده , , Shaomeng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
5949
To page
5951
Abstract
An efficient method was developed for the asymmetric synthesis of 2′-alkyl-4′aryl-1H-spiro[indole-3,3′-pyrrolidin]-2-ones, which are potential inhibitors of the p53–MDM2 interaction. Our X-ray crystallographic analysis revealed that this 1,3-dipolar cycloaddition proceeds with high stereoselectivity but differently from previously published results.
Keywords
Asymmetric 1 , Spirooxindoles , Inhibitors of the p53–MDM2 interaction , 3-dipolar cycloaddition
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846531
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