Title of article
The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates
Author/Authors
Mandal، نويسنده , , Ashis Baran and Augustine، نويسنده , , John Kallikat and Quattropani، نويسنده , , Anna and Bombrun، نويسنده , , Agnes، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
6033
To page
6036
Abstract
A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1–7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.
Keywords
Picoline , Pyridine carbaldehydes , Dibromomethyl , Hydrolysis , Scaffolds
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846549
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