Title of article
A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone
Author/Authors
Conreaux، نويسنده , , David and Bossharth، نويسنده , , Emmanuel and Monteiro، نويسنده , , Nuno and Desbordes، نويسنده , , Philippe and Balme، نويسنده , , Geneviève، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7917
To page
7920
Abstract
It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-1-methyl-2-pyridone, a valuable building block for heterocycle synthesis.
Keywords
desulfonylation , Tetrabutyl ammonium iodide , 4-Alkoxy-2-pyridones , N-Alkylation
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847331
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