Title of article
Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine and its analogues
Author/Authors
F?kov?، نويسنده , , Helena and Pour، نويسنده , , Milan and Kune?، نويسنده , , Ji?? and ?enel، نويسنده , , Petr، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
8137
To page
8140
Abstract
A novel cytotoxic butenolide alkaloid, uncinine, has been synthesized for the first time in 8 steps from propargyl alcohol. The sequence features a mild and efficient tandem carbonylative lactonization of a β-iodoenone precursor using an inorganic base at 1 atm CO, and an indirect attachment of the pyrrolidinone ring via nucleophilic substitution with methyl γ-aminobutyrate.
Keywords
butenolides , Alkaloids , Carbonylative lactonization , cytotoxicity , Pd catalysis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847472
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