Synthesis of P-chirogenic diarylphosphinoacetic acids and their proline derivatives for palladium-catalysed allylic alkylation reactions

The synthesis of P-chirogenic diarylphosphinocarboxylic acids was achieved, from which a new class of amido- and amino-diphosphine ligands (PNP*) were derived, containing an l-proline backbone. The catalytic activities of the novel ligands were evaluated in the palladium-catalysed allylic alkylation reaction of 1,3-diphenylpropenyl acetate.