Title of article
A practical synthesis of fully protected l-γ-carboxyglutamic acid
Author/Authors
Jiang، نويسنده , , Sheng and Lai، نويسنده , , Christopher C. and Kelley، نويسنده , , James A. and Roller، نويسنده , , Peter P.، نويسنده ,
Issue Information
دوماهنامه با شماره پیاپی سال 2006
Pages
3
From page
23
To page
25
Abstract
We have developed a new synthetic route for the preparation of Fmoc protected l-γ-carboxyglutamic acid in 60% overall yield (>99% ee) via a six-step synthesis from d-Garner’s aldehyde. An aldol condensation and the selective cleavage of the acetonide protective group are key steps.
Keywords
l-?-Carboxyglutamic acid , d-Garner’s aldehyde , Aldol condensation , stereoselective synthesis
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1847953
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