Title of article
Synthesis of mono Nα-trifluoroethylated cyclic dipeptides
Author/Authors
DesMarteau، نويسنده , , Darryl D. and Lu، نويسنده , , Changqing، نويسنده ,
Issue Information
دوماهنامه با شماره پیاپی سال 2006
Pages
4
From page
561
To page
564
Abstract
Trifluoroethylated N-termini in linear dipeptides l-TyrXOR [X = Gly, d-Ala, l-Leu, l-Phe, and l-Glu; R = H, Me, Et] exhibit sufficient nucleophilicity to give piperazine-2,5-dione ring formation through intramolecular cyclization reaction in acidic aqueous solutions. The reactions occur in high yield and with absolute configuration retention.
Keywords
Trifluoroethylation , nucleophilicity , Intramolecular cyclization , Cyclic dipeptide
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1848481
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