Title of article
A total synthesis of spiruchostatin A
Author/Authors
Doi، نويسنده , , Takayuki and Iijima، نويسنده , , Yusuke and Shin-ya، نويسنده , , Kazuo and Ganesan، نويسنده , , A. and Takahashi، نويسنده , , Takashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
1177
To page
1180
Abstract
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization using the Shiina method.
Keywords
spiruchostatin , Cyclic depsipeptide , natural product synthesis , Asymmetric aldol reaction
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1848832
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