Title of article
Macrolactam formation catalyzed by the thioesterase domain of vicenistatin polyketide synthase
Author/Authors
Kudo، نويسنده , , Fumitaka and Kitayama، نويسنده , , Takashi and Kakinuma، نويسنده , , Katsumi and Eguchi، نويسنده , , Tadashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
1529
To page
1532
Abstract
The excited thioesterase (TE) domain from the vicenistatin polyketide synthase (PKS) efficiently catalyzed the macrolactam formation of the N-acetylcysteamine thioester of the seco-amino acid of the aglycon vicenilactam. This result indicates that the vicenistatin PKS TE domain cyclizes the extended polyketide chain on the ACP domain in the PKS. Furthermore, the simple ethyl ester of the seco-amino acid was also found to be used as a substrate of the TE domain with similar efficiency.
Keywords
Vicenistatin , polyketide synthase , thioesterase , Macrolactam formation
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849060
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