Title of article
Suppression of epimerization due to selectivity leakage: an application towards the total synthesis of (−)-centrolobine
Author/Authors
Lee، نويسنده , , Cheng-Hsia Angeline and Loh، نويسنده , , Teck-Peng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
1641
To page
1644
Abstract
An InCl3-mediated Prins cyclization of homoallylic alcohols with aldehydes has been established. The enantioselectivities of the trisubstituted tetrahydropyrans are almost retained through the suppression of epimerization. The synthetic value of this protocol is demonstrated by the total synthesis of (−)-centrolobine.
Keywords
Centrolobine , Epimerization , tetrahydropyrans , Prins cyclization
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849126
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