Title of article
One-step exchange-labelling of pyridines and other N-heteroaromatics using deuterium gas: catalysis by heterogeneous rhodium and ruthenium catalysts
Author/Authors
Alexakis، نويسنده , , Efstathios and Jones، نويسنده , , John R. and Lockley، نويسنده , , William J.S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
5025
To page
5028
Abstract
A wide range of pyridines and other nitrogen heteroaromatics can be labelled with deuterium at room temperature and pressure by isotopic exchange with deuterium gas in THF in the presence of rhodium black, ruthenium black or 5% rhodium on alumina. The labelling is rapid, isotope efficient and applicable to both electron-rich and electron-poor substrates. In a few cases, a degree of reduction accompanies the exchange.
Keywords
Ruthenium black , Rhodium black , Rhodium on alumina , isotope-exchange , Deuterium gas , pyridine , N-Heteroaromatic , ?-Exchange , Deuteration , Tritiation
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851287
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