Title of article
Modification of guanine residues in PNA-synthesis by PyBOP
Author/Authors
Pritz، نويسنده , , Stephan E. Wolf، نويسنده , , Yvonne and Klemm، نويسنده , , Clementine and Bienert، نويسنده , , Michael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
5893
To page
5896
Abstract
The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O4-phosphonium compounds of the nucleobase guanine which can be converted into C4-modified guanine-derived PNAs by nucleophiles.
Keywords
Coupling reagents , PNA synthesis , PyBOP , guanine , HATU
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851961
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