Title of article
An environmentally friendly and cost effective synthesis of estradiol featuring two novel reagents: Si(0)/KF and PMHS/hexamethyldisiloxane/pTSA
Author/Authors
Lim، نويسنده , , Chongsoo and Evenson، نويسنده , , Gerald N. and Perrault، نويسنده , , William R. and Pearlman، نويسنده , , Bruce A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
6417
To page
6420
Abstract
Si(0)/KF is introduced as a strong, inexpensive, environmentally friendly, and safe reagent for ‘dissolving metal’-type reduction. PMHS/hexamethyldisiloxane/pTSA is introduced as an inexpensive substitute for Et3SiH/TFA for ‘ionic hydrogenation’, where the hexamethyldisiloxane functions as a capping agent to block the oligomeric silicone by-product from cross-linking to a gel, rubber, or plastic. An environmentally friendly and cost effective synthesis of estradiol is described which showcases these new reagents.
Keywords
Silicon(0) , Potassium Fluoride , PMHS/hexamethyldisiloxane/pTSA , ATD , estradiol
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852262
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