Title of article
Synthesis of alkyl (R)-lactates and alkyl (S,S)-O-lactyllactates by alcoholysis of rac-lactide using Novozym 435
Author/Authors
Jeon، نويسنده , , Nan Young and Ko، نويسنده , , Sung-Jin and Won، نويسنده , , Keehoon and Kang، نويسنده , , Han-Young and Kim، نويسنده , , Bum Tae and Lee، نويسنده , , Yeon Soo and Lee، نويسنده , , Hyuk، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
6517
To page
6520
Abstract
Enzymatic alcoholysis of rac-lactide for kinetic resolution was carried out in organic solvents. Effects of organic solvent, reaction temperature, and alcohol as a nucleophile were also investigated in Novozym 435-catalyzed alcoholysis of rac-lactide. Both alkyl (R)-lactate and alkyl (S,S)-O-lactyllactate were simultaneously obtained in high yields (>45%) and high enantiopurities (>97% ee) through Novozym 435-catalyzed ring-opening of rac-lactide and subsequent enantioselective alcoholysis of the resultant alkyl O-lactyllactate.
Keywords
Alkyl O-lactyllactate , rac-Lactide , kinetic resolution , Alkyl lactate , Novozym 435
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852323
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