Title of article
General strategy for a short and efficient synthesis of 3-hydroxy-4-methylprolines (HMP)
Author/Authors
Mohapatra، نويسنده , , Debendra K. and Mondal، نويسنده , , Dhananjoy and Chorghade، نويسنده , , Mukund S. and Gurjar، نويسنده , , Mukund K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
9215
To page
9219
Abstract
The non-proteinogenic amino acid 3-hydroxy-4-methylproline (HMP) is an active constituent of some potent antimicrobials including echinocandins, nostopeptins, pneumocandins, sporiofungin and mulundocandins. A synthesis has been achieved in 10 steps with 29% overall yield; the Evans’ aldol reaction using Crimmins’ modified method was pivotal to the success of the strategy.
Keywords
3 , Crimmins’ aldol reaction , Garner’s aldehyde , non-proteinogenic amino acids , RuO4 mediated oxidation , 4-Disubstituted proline
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1853726
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