Title of article
N-Alkyl cysteine-assisted thioesterification of peptides
Author/Authors
Hojo، نويسنده , , Hironobu and Onuma، نويسنده , , Yuko and Akimoto، نويسنده , , Yuri and Nakahara، نويسنده , , Yuko and Nakahara، نويسنده , , Yoshiaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
25
To page
28
Abstract
A new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc SPPS. The synthetic peptides released from resin by TFA were readily converted to the peptide thioester in aqueous 3-mercaptopropionic acid (MPA) without significant side reactions.
Keywords
Fmoc solid-phase method , N–S Acyl transfer , Peptide thioester
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1853813
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