Title of article
The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3
Author/Authors
Donghak and Cryle، نويسنده , , Max J. and Matovic، نويسنده , , Nick J. and De Voss، نويسنده , , James J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
133
To page
136
Abstract
The stereochemical preference for the cytochrome P450BM3-catalysed hydroxylation of tetradecanoic and pentadecanoic acids has been determined via comparison with authentic non-racemic standards utilising enantioselective HPLC. The sub-terminal hydroxylation of these fatty acids by P450BM3 is highly selective for the formation of the R-alcohols. This is the same enantioselectivity as is seen for hexadecanoic acid oxidation but contrasts with a previous report of S-hydroxylation of pentadecanoic acid by P450BM3.
Keywords
cytochrome P450 , BM3 , CYP102A1 , Regiochemistry , Oxidation mechanism , Stereochemistry
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1853858
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