Title of article
Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide
Author/Authors
Fujino، نويسنده , , Aya and Asano، نويسنده , , Masayoshi and Yamaguchi، نويسنده , , Hitomi and Shirasaka، نويسنده , , Naoki and Sakoda، نويسنده , , Akiko and Ikunaka، نويسنده , , Masaya and Obata، نويسنده , , Rika and Nishiyama، نويسنده , , Shigeru and Sugai، نويسنده , , Takeshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
979
To page
983
Abstract
Expeditious synthesis of (R)-bicalutamide (1), a synthetic antiandrogen, from enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether (4) was achieved. An engineered Bacillus subtilis epoxide hydrolase worked enantioselectively on the racemic epoxide (7) to provide the above starting material in highly enantiomerically enriched state.
Keywords
(R)-1-Benzyloxy-2-methylpropane-2 , Bicalutamide , kinetic resolution , 3-diol , Diol , epoxide hydrolase
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854137
Link To Document