Title of article
Preparation of clarithromycin. Selective 6-O-methylation of the novel erythromycin A 9-O-(2-pyrimidyl)oxime
Author/Authors
Brunet، نويسنده , , Ernesto and Muٌoz، نويسنده , , Dulce Marيa and Parra، نويسنده , , Francisco and Mantecَn، نويسنده , , Susana and Juanes، نويسنده , , Olga and Rodrيguez-Ubis، نويسنده , , Juan Carlos and Carmen Cruzado، نويسنده , , Ma and Asensio، نويسنده , , Ramَn، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
1321
To page
1324
Abstract
A new method for the preparation of clarithromycin is described through the highly regioselective O-methylation at C(6)–OH of the novel derivative 9-pyrimidyloxime erythromycin A. The facile synthesis of 6,11-O-dimethyl- and 6,11,12-O-trimethyl erythromycin A is also reported. These compounds are useful as standards to assess clarithromycin purity in quality control processes.
Keywords
Regioselective methylation , Erythromycin , Clarithromycin
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854250
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