Title of article
Asymmetric Michael addition of α-nitro-ketones using catalytic peptides
Author/Authors
Linton، نويسنده , , Brian R. and Reutershan، نويسنده , , Michael H. and Aderman، نويسنده , , Christopher M. and Richardson، نويسنده , , Elizabeth A. and Brownell، نويسنده , , Kristen R. and Ashley، نويسنده , , Charles W. and Evans، نويسنده , , Catherine A. and Miller، نويسنده , , Scott J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
1993
To page
1997
Abstract
Peptide-based catalysts have been developed that promote the asymmetric Michael addition of nitroalkanes. The most effective peptides contain a β-turn structural element as well as a basic histidine and an arylsulfonamide-protected arginine. Excellent yields with enantioselectivities of up to 74% ee have been observed.
Keywords
Asymmetric catalysis , Michael addition , hydrogen-bonding
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854480
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