A simple and concise catalytic asymmetric entry to tetrahydroxanthenones

The first catalytic asymmetric synthesis of tetrahydroxanthenones is presented. The simple organocatalytic enantioselective domino reactions between salicylic aldehyde derivatives and α,β-unsaturated cyclic ketones proceed with excellent chemoselectivity to give the corresponding tetrahydroxanthenones in moderate to good yields and high enantioselectivities.