Title of article
A tandem enol silane formation-Mukaiyama aldol reaction mediated by TMSOTf
Author/Authors
Downey، نويسنده , , C. Wade and Johnson، نويسنده , , Miles W. She، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
3559
To page
3562
Abstract
A slight excess of silyl trifluoromethanesulfonate mediates a tandem enol silane formation-Mukaiyama aldol reaction in the presence of Hunig’s base. Preformation of the enol silane is unnecessary for efficient reactions, which proceed in 75–97% yield for the addition of aryl methyl ketones and acetate esters to non-enolizable aldehydes. Mechanistic data suggests that free amine is crucial for full conversion.
Keywords
Enol silane , Silyl trifluoromethanesulfonate , Mukaiyama aldol , Silyl triflate
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854983
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