Title of article
A highly efficient resolution protocol for 2′-halo-α-methylbenzylamines
Author/Authors
Klingensmith، نويسنده , , Liane M. and Nadeau، نويسنده , , Kelly A. and Moniz، نويسنده , , George A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
4589
To page
4593
Abstract
A highly efficient resolution protocol for 2′-halo-α-methylbenzylamines is reported. Commercially available and inexpensive mandelic acid can be used for the resolution of the Br, Cl, and F derivatives to >99% de in a single crystallization. In addition, the reduction of acetophenone oximes using borane-dimethylsulfide is presented as a method for the preparation of racemic amine precursors.
Keywords
Reduction , Halogenated , RESOLUTION , enantioselective
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1855377
Link To Document