Pd-catalyzed aerobic oxidative coupling of anilides with olefins through regioselective C–H bond activation

Pd-catalyzed aerobic oxidative coupling of anilides with olefins was achieved through selective C–H bond activation. Compared to the previous studies, not only did we successfully use molecular oxygen to replace the chemical oxidant, but we also obtained improved yields for a number of substrates. The reaction tended to give high yields for electron-rich anilides and electron-deficient olefins, with a best yield up to 91%.