Title of article
Regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles via three-component coupling of secondary alcohols, TMSN3 and alkynes
Author/Authors
Sreedhar، نويسنده , , B. and Reddy، نويسنده , , P. Surendra and Krishna، نويسنده , , V. Rama، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
5831
To page
5834
Abstract
1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields via a three-component coupling of secondary alcohols, alkynes and trimethylsilyl azide (TMSN3). This one-pot reaction occurs through in situ generation of an azide from the alcohol and TMSN3, followed by 1,3-dipolar cycloaddition of the terminal alkyne to afford the corresponding disubstituted triazoles.
Keywords
1 , 2 , 4-Disubstituted 1 , 3-Triazoles , 1 , 3-dipolar cycloaddition , Secondary alcohols , Azide , Cu(OTf)2
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856032
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