Title of article
A novel three-component tandem protocol for the regioselective synthesis of 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines
Author/Authors
Karthikeyan، نويسنده , , Subramanian Vedhanarayanan and Perumal، نويسنده , , Subbu and Balasubramanian، نويسنده , , K.K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
6133
To page
6136
Abstract
A series of new substituted 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines were synthesised by one-pot, three-component tandem reactions of 5-aryldihydro-3(2H)-thiophenone, aromatic aldehydes and pyrrolidine/piperidine under solvent-free microwave irradiation. This facile transformation occurs presumably via a tandem enamine formation–carbonyl addition–dehydration–isomerisation sequence.
Keywords
Thienylpiperidine , 3-Thiophenone , Tandem sequence , aldehyde , microwave , Thienylpyrrolidine
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856197
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