Title of article
Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives
Author/Authors
Decostaire، نويسنده , , Isidore P. and Lelièvre، نويسنده , , Dominique and Aucagne، نويسنده , , Vincent and Delmas، نويسنده , , Agnès F.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
6523
To page
6526
Abstract
In this study, the challenging Pd(0)-catalyzed Nα-Aloc removal from a proline residue using Me2NH·BH3 or PhSiH3 as allyl scavengers has been investigated. Standard conditions led to a large amount of an allylamine byproduct. A careful study of the reactions allowed us to design the optimal conditions for the quick and quantitative formation of the desired product, while taking advantage of a synergic effect between hydride and proton donors.
Keywords
Proline protection , Aloc , Solid phase peptide synthesis , allylamine , Alloc
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1856419
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