Title of article
Carbohydration of 1,4,8,11-tetraazacyclotetradecane (cyclam): synthesis and binding properties toward concanavalin A
Author/Authors
Stephan، نويسنده , , Holger and Rِhrich، نويسنده , , Anika and Noll، نويسنده , , Steffi and Steinbach، نويسنده , , Jِrg and Kirchner، نويسنده , , Ralf P Seidel، نويسنده , , Jürgen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
8834
To page
8838
Abstract
Two novel glycocluster ligands with cyclam core bearing thiourea-linked d-glucose and 2-acetamido-2-deoxy-d-glucose at the periphery have been synthesized. The interaction with concanavalin A has been studied by isothermal titration microcalorimetry for characterizing protein-ligand interactions. The sugar-containing multivalent ligands showed higher association affinity compared to the sugar monomers, which is attributed to an entropy driven glycoside clustering effect.
Keywords
carbohydrates , Thiourea-bridging , Lectins , Isothermal titration microcalorimetry , Cyclam
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1857513
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