Title of article
Synthesis of thiophene derivatives via palladium-catalyzed coupling reactions
Author/Authors
Arai، نويسنده , , Nobumichi and Miyaoku، نويسنده , , Takayuki and Teruya، نويسنده , , Shota and Mori، نويسنده , , Atsunori، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1000
To page
1003
Abstract
Thiophene derivatives with multiple substitutions are prepared from vinylidene bromide, which is synthesized by the reaction of thiophene-2-carboxaldehyde with carbon tetrabromide in the presence of PPh3, as a core molecule through several coupling reactions such as Suzuki–Miyaura coupling and palladium-catalyzed CH arylation. The reactions with a wide variety of organic halides lead to a series of substituted thiophene derivatives in moderate to good yields.
Keywords
Thiophene , Corey–Fuchs reaction , palladium catalyst , Suzuki–Miyaura coupling , CH arylation
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858132
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