Title of article
First total synthesis of sterenins A, C and D
Author/Authors
Shinozuka، نويسنده , , Tsuyoshi and Yamamoto، نويسنده , , Yuko and Hasegawa، نويسنده , , Toru and Saito، نويسنده , , Keiji and Naito، نويسنده , , Satoru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1619
To page
1622
Abstract
The first total synthesis of sterenins A, C and D, potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is described. The prenyl group was regioselectively introduced by a Claisen rearrangement, whereas the construction of an isoindolinone skeleton was accomplished by the lactamization of lactones assisted by a phenolic hydroxyl group.
Keywords
11b-HSDs , Sterenin , Isoindolinone , Claisen rearrangement , Metabolic Diseases
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858434
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