Title of article
A novel facile synthesis of carbamoylmethylphosphine oxides in ionic liquids
Author/Authors
Sharova، نويسنده , , Elena V. and Artyushin، نويسنده , , Oleg I. and Shaplov، نويسنده , , Alexander S. and Myasoedova، نويسنده , , Galina V. and Odinets، نويسنده , , Irina L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
1641
To page
1644
Abstract
A convenient access to carbamoylmethylphosphine oxides (CMPO) in up to 96% isolated yield is developed via direct amidation of diphenylphosphoryl acetic acid in an ionic liquid as a recyclable reaction medium in the presence of triphenyl phosphite. The influence of the nature of the amine and anion and cation structure in the ionic liquid on the reaction rate and yields of the products are also investigated. 1-Butyl-3-methylimidazolium bromide [bmim]Br and trihexyltetradecylphosphonium chloride [P(C6H13)3(C14H29)]Cl proved to be the best media for carrying out this reaction.
Keywords
Carbamoylmethylphosphine oxides , Phosphorylacetic acid , Amidation , Ionic liquids , triphenyl phosphite
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858444
Link To Document