Title of article
Radical fluoroarylation in radiochemical synthesis
Author/Authors
Hultsch، نويسنده , , Christina and Blank، نويسنده , , Olga and Wester، نويسنده , , Hans-Jürgen and Heinrich، نويسنده , , Markus R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
1881
To page
1883
Abstract
In this study, we report on the radical [18F]fluoroarylation of different olefins using 4-[18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[18F]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of 18F-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30–45% overall radiochemical yield starting from [18F]fluoride.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1858570
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