A facile synthesis of aminomethylene bisphosphonates through rhodium carbenoid mediated N–H insertion reaction. Application to the preparation of powerful uranyl ligands

A straightforward procedure ensuring the anchoring of bisphosphonate moiety onto aromatic amines is described. The procedure yields aminoaryl 1,1-bisphosphonates known to display multiple biological activities. The described methodology has also been applied to the synthesis of ligands whose uranyl-binding properties have been studied.